Ricki Lewis

The Egyptian fruit bat's immune system enables it to peacefully co-exist with Marburg virus, which can cause a swiftly deadly infection in humans. Although Marburg virus disease affects only a few dozen or hundred people a year, the case:fatality ratio in the scattered outbreaks ranges from 50% to 100%. A recent paper in Cell that explores the bat's genome reveals how its immune system may prevent the virus from harming the flying mammals, which may hold clues for preventing or treating the infection in humans.
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While pharmaceutical companies focus on drug discovery for Ebola virus disease, a powerful clue is coming from a rare “Jewish genetic disease” that destroys the brain. People with Niemann-Pick C1 disease can’t get Ebola, adding to the list of disease pairs that arise from a fascinating form of natural selection.

Balanced polymorphism, aka heterozygote advantage, is a terrific illustration of ongoing evolution. And it pits the human body against all sorts of invaders – prions, viruses, bacteria, protozoa, and fungi. Read More 

My last post continued Emmanuel Gokpolu’s reporting from Ebola ground zero in Liberia. Ebola interrupted Eman’s medical education, so now he is educating his people about strategies to minimize risk of infection.

Eman and I began a very special friendship when he first contacted me when using my human genetics textbook in college. Right now he is in a hospital with a fever, after finally convincing the staff to admit him. It might be a flare-up of his malaria, we don't yet know.

This post picks up in early October, when Ebola suddenly jumped from a topic rarely reported in the U.S. ,to major news when it arrived here.  Read More 

Emmanuel Gokpolu, who lives in Liberia, calls me Mom, although he has a wonderful real mother. In Africa, family isn’t only about DNA.

Eman contacted me in 2007, after using my human genetics textbook in college. My husband Larry and I had been putting him through medical school in Monrovia -- until Ebola happened. Now the funds go for gloves, long sleeve shirts, detergents, food and medicine, to keep Eman and his family, including his almost-one-year-old son, Larry, safe.

This week Eman asked me to share his emails, which began arriving before many people here had heard of Ebola virus disease, or cared much about it if they had. The disease seemed, and was, half a world away.

The world is a small place. Read More 

(An updated version of this post appears at my Public Library of Science blog DNA Science.)


“That’s not Ebola!” I said to the vendor standing beside a display of boxer shorts festooned with pathogens, at a National Association of Biology Teachers conference a few years ago.

“No, that’s Ebola. Read the tag.”

“The tag’s wrong. It’s influenza. See the spokes on the surface? Ebola looks like a long soup ladle.”

He didn’t believe me, but the website was corrected a few months later. I still have my faux Ebola shorts somewhere.

JUST 7 GENES
The stark seeming-simplicity of the Ebola virus flashes across my mind whenever I get email from Emmanuel, a medical student in Liberia. My husband and I have been supporting his education since he contacted me in 2007 after reading Human Genetics: Concepts and Applications, my textbook very soon to be published in its 11th edition. The story of our relationship, today between two families, is here, but since then Eman has become a father, naming his son after my husband Larry.

Eman is our son in the African sense, not based on DNA. Escalating panic pervades his emails of the past few days. Right now he has a high fever, headache, and diarrhea, but says it is "only typhoid, not to worry."

The electronic communication with our Liberian friend is odd in the face of the crumbling infrastructure, the abandoned hospitals and schools. He taps on a phone, too terrified to enter an Internet cafe. And I’m mortified that the NBC nightly news placed a lengthy NASCAR crash report before an Ebola update. Eman wants to know why the US didn’t pay attention until the arrival here of two white, American patients. So do I.  Read More