I’m borrowing Swift’s essay title to bring up another outrageous idea: analyzing forensic DNA databases for a genetic signature of criminality. Read More
Genetic Linkage
Comparing Adam Lanza’s DNA to Forensic DNA Databases: A Modest Proposal
January 3, 2013
In 1729, Jonathan Swift of Gulliver’s Travels fame published a satirical essay called "A Modest Proposal." He suggested that a cure for poverty was for poor people to sell their children to rich people as food.
I’m borrowing Swift’s essay title to bring up another outrageous idea: analyzing forensic DNA databases for a genetic signature of criminality. Read More
I’m borrowing Swift’s essay title to bring up another outrageous idea: analyzing forensic DNA databases for a genetic signature of criminality. Read More
2 Comments
The Curious Genetics of Werewolves
December 27, 2012
Growing up in the 1960s, I collected monster cards: The 60-foot-man and the 50-foot woman; body doubles gestating in giant seed pods; unseen Martians that sucked people into sand pits and returned them devoid of emotion, with telltale marks on the back of the neck. One card featured a very young Michael Landon in “I Was a Teenage Werewolf.”
Forgive my lapse in political correctness, but I recalled those cards when I saw the word “hypertrichosis” in a recent paper in PLOS Genetics because, unfortunately, the condition is also known historically as “werewolf syndrome.” Read More
Forgive my lapse in political correctness, but I recalled those cards when I saw the word “hypertrichosis” in a recent paper in PLOS Genetics because, unfortunately, the condition is also known historically as “werewolf syndrome.” Read More
Gene Therapy for Canavan Disease: Max’s Story
December 19, 2012
I’m thrilled about the encouraging gene therapy results just published in Science Translational Medicine from Paola Leone, PhD and R. Jude Samulski, PhD, and colleagues. “Long-term follow-up after gene therapy for Canavan Disease” updates a project that has its origins in the mid 1990s. Canavan disease is a brain disorder present from birth.
I’ve been following some of the kids who’ve had the gene therapy. One patient in particular – Max Randell – has been in my human genetics textbook since age three, his progress updated with each edition. Read More
I’ve been following some of the kids who’ve had the gene therapy. One patient in particular – Max Randell – has been in my human genetics textbook since age three, his progress updated with each edition. Read More
Excerpt about Canavan disease from "The Forever Fix: Gene Therapy and the Boy Who Saved It"
December 19, 2012
The excerpt below supplements the blog entry that is beneath it and also at Public Library of Science. It is from The Forever Fix: Gene Therapy and the Boy Who Saved It, (St. Martin's Press, 2012).
I sat at a table with Paola, Mike, Max and Max’s charming little brother Alex, who was eight going on twenty-eight. While the adults ate chicken alfredo (except for vegetarian Paola) and the kids downed chicken fingers and fries, Mike leaned over Max, pulled up his shirt, and deftly attached a bag of cream-colored stuff to the feeding tube coming from his son’s stomach, holding it aloft for the food to go in. At the front of the ballroom, Ilyce, svelte in a shimmering blue gown, was getting ready for her annual thank-you. Read More
I sat at a table with Paola, Mike, Max and Max’s charming little brother Alex, who was eight going on twenty-eight. While the adults ate chicken alfredo (except for vegetarian Paola) and the kids downed chicken fingers and fries, Mike leaned over Max, pulled up his shirt, and deftly attached a bag of cream-colored stuff to the feeding tube coming from his son’s stomach, holding it aloft for the food to go in. At the front of the ballroom, Ilyce, svelte in a shimmering blue gown, was getting ready for her annual thank-you. Read More
When An Arm Is Really A Leg
December 14, 2012
Flipping the X-ray showed Stefan Mundlos, MD, that his hunch was right – the patient’s arms were so odd and stiff because the elbows were actually knees.
The recent report from Dr. Mundlos’ group at the Max Planck Institute for Molecular Genetics, complete with a genetic explanation for the condition, flew under the radar of the press-release-driven science news aggregators. But I noticed it because I worked on this sort of thing in grad school – flies with legs growing out of their heads. Read More
The recent report from Dr. Mundlos’ group at the Max Planck Institute for Molecular Genetics, complete with a genetic explanation for the condition, flew under the radar of the press-release-driven science news aggregators. But I noticed it because I worked on this sort of thing in grad school – flies with legs growing out of their heads. Read More
The Battle of the Prenatal Tests
December 9, 2012
The young couple looked at me expectantly as I re-read the amnio report and tried to decide what to tell them.
“The ultrasound from 15 weeks looks fine,” I stalled, trying to present the good news first.
“What about the amnio?”
“Well, there is something unusual. It’s the Y chromosome. Part of it appears to be flipped. What we call an inversion. It’s a little like if the exits on a highway turned around,” I explained.
The couple looked at each other, puzzled, then back at me, and he reached for her hand.
“What does that mean?” they both asked. Read More
“The ultrasound from 15 weeks looks fine,” I stalled, trying to present the good news first.
“What about the amnio?”
“Well, there is something unusual. It’s the Y chromosome. Part of it appears to be flipped. What we call an inversion. It’s a little like if the exits on a highway turned around,” I explained.
The couple looked at each other, puzzled, then back at me, and he reached for her hand.
“What does that mean?” they both asked. Read More
Cialis Comes Full Circle – Help for Muscular Dystrophy
November 29, 2012
Becker muscular dystrophy is a muscle-wasting disease that is rarer and less severe than the more familiar Duchenne type. Both conditions are basically untreatable. But according to a study published today in Science Translational Medicine, Cialis may alleviate the associated muscle fatigue and damage.
Yes, Cialis. The erectile dysfunction drug.
To anyone who’s followed the Viagra story, use of its cousin Cialis to treat muscle disease is not so much repurposing as it is a logical extension, based on regulating blood flow.
Viagra, developed in 1989, began its ascent three years later, when participants in a clinical trial to treat angina, which is chest pain due to blocked blood flow, reported strikingly improved erections. Taking a pill to treat what was about to evolve from “impotence” to “erectile dysfunction” trumped penile implants and injections, or older approaches of ingesting camel hump fat, jackal bile, or various herbs. Pfizer introduced Viagra to the world in 1998. Read More
Yes, Cialis. The erectile dysfunction drug.
To anyone who’s followed the Viagra story, use of its cousin Cialis to treat muscle disease is not so much repurposing as it is a logical extension, based on regulating blood flow.
Viagra, developed in 1989, began its ascent three years later, when participants in a clinical trial to treat angina, which is chest pain due to blocked blood flow, reported strikingly improved erections. Taking a pill to treat what was about to evolve from “impotence” to “erectile dysfunction” trumped penile implants and injections, or older approaches of ingesting camel hump fat, jackal bile, or various herbs. Pfizer introduced Viagra to the world in 1998. Read More
JIM: More Compelling Than GATTACA
November 24, 2012
For 15 years, the film GATTACA has been synonymous with “genetic dystopian future,” and has become a mainstay of genetics classrooms. But I’ve found a better film. It’s called, simply, JIM.
I never could connect with GATTACA, the dark tale of an assumed genetic identity in a society where the quality of one’s genome dictates all. Perhaps because in 1997, the pre-genome era, the idea of ordering a DNA test over the Internet was still science fiction. But ironically GATTACA’s “not-too-distant” future, in which a genetically inferior “invalid” impersonates a “valid” to achieve a dream, sets up a too-obvious conflict, with the details and resolution contrived. I know this from years of reading fiction and watching soap operas. Read More
I never could connect with GATTACA, the dark tale of an assumed genetic identity in a society where the quality of one’s genome dictates all. Perhaps because in 1997, the pre-genome era, the idea of ordering a DNA test over the Internet was still science fiction. But ironically GATTACA’s “not-too-distant” future, in which a genetically inferior “invalid” impersonates a “valid” to achieve a dream, sets up a too-obvious conflict, with the details and resolution contrived. I know this from years of reading fiction and watching soap operas. Read More
Mice With Human Liverlets Test New Drugs
November 17, 2012
“Scientists at Stanford have produced mice with human brains, pigs with human blood flowing through their veins, and a human born to mice parents and mice with human heads.”
So wrote a student summarizing the “Genetically Modified Organisms” chapter of my human genetics textbook a few years ago. Two of the four comments are true, sort of.
Read More
So wrote a student summarizing the “Genetically Modified Organisms” chapter of my human genetics textbook a few years ago. Two of the four comments are true, sort of.
Read More
Why I Don't Want to Know My Genome Sequence
November 2, 2012
Famous folk have been writing about their genome sequences for a few years now. But when I received two such reports at once last week – about genetics researcher Ron Crystal, MD, and a hypothetical (I think) story about President Obama, I knew it was time to take action.
Or, in my case, inaction. Read More
Or, in my case, inaction. Read More