![](https://sbx-attachments-production.s3.us-east-2.amazonaws.com/l2dx27htbwus4ilckgau4ngj4rrq?response-content-disposition=inline%3B%20filename%3D%22Human-X-and-Y-chromosomes-and-their-role-in-determining-the-sex-of-the-child-svg.png%22%3B%20filename%2A%3DUTF-8%27%27Human-X-and-Y-chromosomes-and-their-role-in-determining-the-sex-of-the-child-svg.png&response-content-type=image%2Fpng&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIA6MHW4YOXXGMMU2FH%2F20240908%2Fus-east-2%2Fs3%2Faws4_request&X-Amz-Date=20240908T013247Z&X-Amz-Expires=172800&X-Amz-SignedHeaders=host&X-Amz-Signature=ebae010db50c6797fc24e88f7fc321501388ff8c6dd4ddee74c7e892f2388d26)
Sequencing our genomes is a 21rst century phenomenon. Discrimination based on genetics dates back to the start of the eugenics movement in the 1880s. Will an effort to determine the sex chromosome constitutions of nearly 600,000 men whose DNA is being analyzed in the Million Veteran Program provide helpful health information – or highlight another possible source of genetic judgment?
Researchers at the University of Colorado Anschutz Medical Campus and collaborators across the US report the largest and most diverse study of men with extra X or Y chromosomes in the US. Their findings appear in the March 29, 2024 JAMA Network Open. The Million Veteran Program is a national effort considering how genes, lifestyle, military experiences, and environmental exposures affect health and wellness among veterans. It launched in 2011.
The Biology of Sex Chromosomes